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Proteasome Activator Enhances Survival of Huntington's Disease Neuronal Model Cells
In patients with Huntington's disease (HD), the proteolytic activity of the ubiquitin proteasome system (UPS) is reduced in the brain and other tissues. The pathological hallmark of HD is the intraneuronal nuclear protein aggregates of mutant huntingtin. We determined how to enhance UPS functio...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2007
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1800909/ https://ncbi.nlm.nih.gov/pubmed/17327906 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0000238 |
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