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Protease-activated receptor 1 is the primary mediator of thrombin-stimulated platelet procoagulant activity

The activation of human platelets by thrombin is mediated primarily by protease-activated receptors (PARs). PAR1 and PAR4 are present on human platelets and are activated by the hexapeptides SFLLRN and GYPGQV, respectively. To further characterize the involvement of PAR1 and PAR4 in platelet activat...

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Autores principales: Andersen, Henrik, Greenberg, Daniel L., Fujikawa, Kazuo, Xu, Wenfeng, Chung, Dominic W., Davie, Earl W.
Formato: Artigo
Lenguaje:Inglês
Publicado: The National Academy of Sciences 1999
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC18009/
https://ncbi.nlm.nih.gov/pubmed/10500152
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