Synovial inflammation does not change in the absence of effective treatment: implications for the use of synovial histopathology as biomarker in early phase clinical trials in rheumatoid arthritis

OBJECTIVES: To determine the impact on synovial histopathology of changes in clinical disease activity in the absence of effective treatment. METHODS: Twelve patients with active RA not receiving effective treatment were studied over a 14 week period. Synovial biopsy specimens obtained at baseline a...

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Main Authors: Baeten, D, Houbiers, J, Kruithof, E, Vandooren, B, Van den Bosch, F, Boots, A M, Veys, E M, Miltenburg, A M M, De Keyser, F
Format: Artigo
Jezik:Inglês
Izdano: BMJ Group 2006
Teme:
Extended Report
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1798244/
https://ncbi.nlm.nih.gov/pubmed/16414969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/ard.2005.047852
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