Multistep Resistance Selection and Postantibiotic-Effect Studies of the Antipneumococcal Activity of LBM415 Compared to Other Agents

LBM415 is a peptide deformylase inhibitor active against gram-positive bacterial species and some gram-negative species. In multiselection studies, LBM415 had low MICs against all Streptococcus pneumoniae strains tested, regardless of their genotype, and selected resistant clones after 14 to 50 days...

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Bibliographic Details
Main Authors: Kosowska-Shick, Klaudia, Credito, Kim L., Pankuch, Glenn A., DeWasse, Bonifacio, McGhee, Pamela, Appelbaum, Peter C.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2007
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1797776/
https://ncbi.nlm.nih.gov/pubmed/17116666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01150-06
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