Trichostatin A increases SMN expression and survival in a mouse model of spinal muscular atrophy

The inherited motor neuron disease spinal muscular atrophy (SMA) is caused by mutation of the telomeric survival motor neuron 1 (SMN1) gene with retention of the centromeric SMN2 gene. We sought to establish whether the potent and specific hydroxamic acid class of histone deacetylase (HDAC) inhibito...

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Hlavní autoři: Avila, Amy M., Burnett, Barrington G., Taye, Addis A., Gabanella, Francesca, Knight, Melanie A., Hartenstein, Parvana, Cizman, Ziga, Di Prospero, Nicholas A., Pellizzoni, Livio, Fischbeck, Kenneth H., Sumner, Charlotte J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2007
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1797603/
https://ncbi.nlm.nih.gov/pubmed/17318264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI29562
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