Tubulovesicular Structures within Vesicular Stomatitis Virus G Protein-Pseudotyped Lentiviral Vector Preparations Carry DNA and Stimulate Antiviral Responses via Toll-Like Receptor 9

Recombinant lentiviral vectors (LVs) are commonly used as research tools and are being tested in the clinic as delivery agents for gene therapy. Here, we show that Vesicular stomatitis virus G protein (VSV-G)-pseudotyped LV preparations produced by transient transfection are heavily contaminated wit...

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Detalhes bibliográficos
Main Authors: Pichlmair, Andreas, Diebold, Sandra S., Gschmeissner, Stephen, Takeuchi, Yasuhiro, Ikeda, Yasuhiro, Collins, Mary K., Reis e Sousa, Caetano
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1797478/
https://ncbi.nlm.nih.gov/pubmed/17079284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01818-06
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