C5 Modulates Airway Hyperreactivity and Pulmonary Eosinophilia during Enhanced Respiratory Syncytial Virus Disease by Decreasing C3a Receptor Expression

Enhanced respiratory syncytial virus disease, a serious pulmonary disorder that affected recipients of an inactivated vaccine against respiratory syncytial virus in the 1960s, has delayed the development of vaccines against the virus. The enhanced disease was characterized by immune complex-mediated...

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Main Authors: Melendi, Guillermina A., Hoffman, Scott J., Karron, Ruth A., Irusta, Pablo M., Laham, Federico R., Humbles, Alison, Schofield, Brian, Pan, Chien-Hsiung, Rabold, Richard, Thumar, Bhagvanji, Thumar, Adeep, Gerard, Norma P., Mitzner, Wayne, Barnum, Scott R., Gerard, Craig, Kleeberger, Steven R., Polack, Fernando P.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2007
Assuntos:
Pathogenesis and Immunity
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1797434/
https://ncbi.nlm.nih.gov/pubmed/17079327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01783-06
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