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RNAi-based conditional gene knockdown in mice using a U6 promoter driven vector

RNA interference (RNAi) is a powerful tool widely used for studying gene function in a number of species. We have previously developed an approach that allows conditional expression of a polymerase III promoter based small hairpin RNA (shRNA) in mice using the Cre-LoxP system. This approach uses a U...

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Autors principals: Shukla, Vivek, Coumoul, Xavier, Deng, Chu-Xia
Format: Artigo
Idioma:Inglês
Publicat: Ivyspring International Publisher 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1796951/
https://ncbi.nlm.nih.gov/pubmed/17304337
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