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Linkage disequilibrium test implies a large effective population number for HIV in vivo

The effective size of the HIV population in vivo, although critically important for the prediction of appearance of drug-resistant variants, is currently unknown. To address this issue, we have developed a simple virus population model, within which the relative importance of stochastic factors and...

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Main Authors: Rouzine, I. M., Coffin, J. M.
格式: Artigo
語言:Inglês
出版: The National Academy of Sciences 1999
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC17956/
https://ncbi.nlm.nih.gov/pubmed/10485899
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