Transition state heterogeneity in GCN4 coiled coil folding studied by using multisite mutations and crosslinking

We have investigated the folding behavior of dimeric and covalently crosslinked versions of the 33-residue α-helical GCN4-p1 coiled coil derived from the leucine zipper region of the transcriptional activator GCN4. The effects of multisite substitutions indicate that folding occurs along multiple ro...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Moran, Liam B., Schneider, Joel P., Kentsis, Alex, Reddy, Giridher A., Sosnick, Tobin R.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC17946/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10485889/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.19.10699
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