Toward the bilayer proteome, electrospray ionization-mass spectrometry of large, intact transmembrane proteins

Genes encoding membrane proteins comprise a substantial proportion of genomes sequenced to date, but ability to perform structural studies on this portion of the proteome is limited. Electrospray ionization-MS (ESI-MS) of an intact protein generates a profile defining the native covalent state of th...

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Bibliographic Details
Main Authors: Whitelegge, J. P., le Coutre, J., Lee, J. C., Engel, C. K., Privé, G. G., Faull, K. F., Kaback, H. R.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 1999
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC17945/
https://ncbi.nlm.nih.gov/pubmed/10485888
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