Detoxification of environmental mutagens and carcinogens: Structure, mechanism, and evolution of liver epoxide hydrolase

The crystal structure of recombinant murine liver cytosolic epoxide hydrolase (EC 3.3.2.3) has been determined at 2.8-Å resolution. The binding of a nanomolar affinity inhibitor confirms the active site location in the C-terminal domain; this domain is similar to that of haloalkane dehalogenase and...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Argiriadi, Maria A., Morisseau, Christophe, Hammock, Bruce D., Christianson, David W.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1999
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC17935/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10485878/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.19.10637
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