Biochemical characterization of penicillin-resistant and -sensitive penicillin-binding protein 2x transpeptidase activities of Streptococcus pneumoniae and mechanistic implications in bacterial resistance to beta-lactam antibiotics.

To understand the biochemical basis of resistance of bacteria to beta-lactam antibiotics, we purified a penicillin-resistant penicillin-binding protein 2x (R-PBP2x) and a penicillin-sensitive PBP2x (S-PBP2x) enzyme of Streptococcus pneumoniae and characterized their transpeptidase activities, using...

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Detalhes bibliográficos

Publicado no:	J Bacteriol
Principais autores:	Zhao, G, Yeh, W K, Carnahan, R H, Flokowitsch, J, Meier, T I, Alborn, W E, Becker, G W, Jaskunas, S R
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1997
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC179340/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9244281/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.179.15.4901-4908.1997
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