Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.

Two genes (mtmD and mtmE) were cloned and sequenced from the mithramycin producer Streptomyces argillaceus. Comparison with proteins in databases and enzymatic assays after expression in Escherichia coli showed that they encode a glucose-1-phosphate:TTP thymidylyl transferase and a TDP-D-glucose 4,6...

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Publikašuvnnas:	J Bacteriol
Váldodahkkit:	Lombó, F, Siems, K, Braña, A F, Méndez, C, Bindseil, K, Salas, J A
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	American Society for Microbiology (ASM) 1997
Fáttát:	Research Article
Liŋkkat:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC179118/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9150235/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.179.10.3354-3357.1997
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Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.

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