A regulatory gene (ccaR) required for cephamycin and clavulanic acid production in Streptomyces clavuligerus: amplification results in overproduction of both beta-lactam compounds.

A regulatory gene (ccaR), located within the cephamycin gene cluster of Streptomyces clavuligerus, is linked to a gene (blp) encoding a protein similar to a beta-lactamase-inhibitory protein. Expression of ccaR is required for cephamycin and clavulanic acid biosynthesis in S. clavuligerus. The ccaR-...

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Pubblicato in:	J Bacteriol
Autori principali:	Pérez-Llarena, F J, Liras, P, Rodríguez-García, A, Martín, J F
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1997
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC178932/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9068654/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.179.6.2053-2059.1997
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