The VanS sensor negatively controls VanR-mediated transcriptional activation of glycopeptide resistance genes of Tn1546 and related elements in the absence of induction.

Transposon Tn1546 from Enterococcus faecium BM4147 encodes a histidine protein kinase (VanS) and a response regulator (VanR) that regulate transcription of the vanHAX operon encoding a dehydrogenase (VanH), a ligase (VanA), and a D,D-dipeptidase (VanX). These last three enzymes confer resistance to...

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Dettagli Bibliografici

Pubblicato in:	J Bacteriol
Autori principali:	Arthur, M, Depardieu, F, Gerbaud, G, Galimand, M, Leclercq, R, Courvalin, P
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1997
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC178666/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8981985/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.179.1.97-106.1997
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