Altered dosage of the Saccharomyces cerevisiae spindle pole body duplication gene, NDC1, leads to aneuploidy and polyploidy

Saccharomyces cerevisiae cells are exquisitely sensitive to altered dosage of the spindle pole body duplication gene, NDC1. We show that the NDC1 locus is haploinsufficient because diploid yeast cells cannot survive with a single chromosomal copy of the NDC1 gene. Diploid cells with a single copy of...

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Main Authors: Chial, H. J., Giddings, T. H., Siewert, E. A., Hoyt, M. A., Winey, M.
格式: Artigo
語言:Inglês
出版: The National Academy of Sciences 1999
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC17866/
https://ncbi.nlm.nih.gov/pubmed/10468586
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