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VEGF-C–induced lymphangiogenesis in sentinel lymph nodes promotes tumor metastasis to distant sites

The mechanisms by which tumors metastasize to sentinel and distant lymph nodes, and beyond, are poorly understood. We developed transgenic mice that overexpress vascular endothelial growth factor-C (VEGF-C) and green fluorescent protein specifically in the skin and studied the effects of chemically-...

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Detalhes bibliográficos
Main Authors: Hirakawa, Satoshi, Brown, Lawrence F., Kodama, Shohta, Paavonen, Karri, Alitalo, Kari, Detmar, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1785149/
https://ncbi.nlm.nih.gov/pubmed/17032920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-05-021758
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