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VEGF-C–induced lymphangiogenesis in sentinel lymph nodes promotes tumor metastasis to distant sites

The mechanisms by which tumors metastasize to sentinel and distant lymph nodes, and beyond, are poorly understood. We developed transgenic mice that overexpress vascular endothelial growth factor-C (VEGF-C) and green fluorescent protein specifically in the skin and studied the effects of chemically-...

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Détails bibliographiques
Auteurs principaux: Hirakawa, Satoshi, Brown, Lawrence F., Kodama, Shohta, Paavonen, Karri, Alitalo, Kari, Detmar, Michael
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2007
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1785149/
https://ncbi.nlm.nih.gov/pubmed/17032920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-05-021758
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