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Dynamic posttranscriptional regulation of ϵ-globin gene expression in vivo
Functional studies of embryonic ϵ-globin indicate that individuals with β thalassemia or sickle cell disease are likely to benefit from therapeutic, transcriptional derepression of its encoding gene. The success of ϵ-globin gene-reactivation strategies, however, will be tempered by the stability tha...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society of Hematology
2007
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1785088/ https://ncbi.nlm.nih.gov/pubmed/17003365 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-06-027946 |
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