Spontaneous tandem sequence duplications reverse the thermal stability of carboxyl-terminal modified 3-isopropylmalate dehydrogenase.

A mutant strain of Thermus thermophilus which contains deletions in the 3'-terminal region of its leuB gene showed a temperature-sensitive growth phenotype in the absence of leucine. Three phenotypically thermostable mutants were isolated from the temperature-sensitive strain by spontaneous evolutio...

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Detalhes bibliográficos

Publicado no:	J Bacteriol
Principais autores:	Akanuma, S, Yamagishi, A, Tanaka, N, Oshima, T
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC178504/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8892833/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.178.21.6300-6304.1996
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