The Saccharomyces cerevisiae MEC1 gene, which encodes a homolog of the human ATM gene product, is required for G1 arrest following radiation treatment.

The Saccharomyces cerevisiae gene MEC1 represents a structural homolog of the human gene ATM mutated in ataxia telangiectasia patients. Like human ataxia telangiectasia cell lines, mec1 mutants are defective in G2 and S-phase cell cycle checkpoints in response to radiation treatment. Here we show an...

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Publié dans:	J Bacteriol
Auteurs principaux:	Siede, W, Allen, J B, Elledge, S J, Friedberg, E C
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 1996
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC178434/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8824640/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.178.19.5841-5843.1996
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