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BLIMP1 regulates cell growth through repression of p53 transcription

Tight regulation of p53 is essential for maintaining normal cell growth. Here we report that BLIMP1 acts in an autoregulatory feedback loop that controls p53 activity through repression of p53 transcription. p53 binds to and positively regulates BLIMP1, which encodes for a known B cell transcription...

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Hlavní autoři: Yan, Junli, Jiang, Jianming, Lim, Ching Aeng, Wu, Qiang, Ng, Huck-Hui, Chin, Keh-Chuang
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2007
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1784014/
https://ncbi.nlm.nih.gov/pubmed/17264218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0605562104
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