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High-mobility group A1 inhibits p53 by cytoplasmic relocalization of its proapoptotic activator HIPK2
High-mobility group A1 (HMGA1) overexpression and gene rearrangement are frequent events in human cancer, but the molecular basis of HMGA1 oncogenic activity remains unclear. Here we describe a mechanism through which HMGA1 inhibits p53-mediated apoptosis by counteracting the p53 proapoptotic activa...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1784001/ https://ncbi.nlm.nih.gov/pubmed/17290307 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI29852 |
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