High-mobility group A1 inhibits p53 by cytoplasmic relocalization of its proapoptotic activator HIPK2

High-mobility group A1 (HMGA1) overexpression and gene rearrangement are frequent events in human cancer, but the molecular basis of HMGA1 oncogenic activity remains unclear. Here we describe a mechanism through which HMGA1 inhibits p53-mediated apoptosis by counteracting the p53 proapoptotic activa...

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Main Authors: Pierantoni, Giovanna Maria, Rinaldo, Cinzia, Mottolese, Marcella, Di Benedetto, Anna, Esposito, Francesco, Soddu, Silvia, Fusco, Alfredo
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2007
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1784001/
https://ncbi.nlm.nih.gov/pubmed/17290307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI29852
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