Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2

The most common pathology associated with obesity is insulin resistance, which results in the onset of type 2 diabetes mellitus. Several studies have implicated the mammalian target of rapamycin (mTOR) signaling pathway in obesity. Eukaryotic translation initiation factor 4E–binding (eIF4E-binding)...

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Main Authors: Le Bacquer, Olivier, Petroulakis, Emmanuel, Paglialunga, Sabina, Poulin, Francis, Richard, Denis, Cianflone, Katherine, Sonenberg, Nahum
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2007
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1783830/
https://ncbi.nlm.nih.gov/pubmed/17273556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI29528
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