aPKC-mediated phosphorylation regulates asymmetric membrane localization of the cell fate determinant Numb

In Drosophila, the partition defective (Par) complex containing Par3, Par6 and atypical protein kinase C (aPKC) directs the polarized distribution and unequal segregation of the cell fate determinant Numb during asymmetric cell divisions. Unequal segregation of mammalian Numb has also been observed,...

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Hlavní autoři: Smith, Christian A, Lau, Kimberly M, Rahmani, Zohra, Dho, Sascha E, Brothers, Greg, She, Ye Min, Berry, Donna M, Bonneil, Eric, Thibault, Pierre, Schweisguth, François, Le Borgne, Roland, McGlade, C Jane
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2007
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1783459/
https://ncbi.nlm.nih.gov/pubmed/17203073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601495
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