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In the regulation of cytochrome P450 genes, phenobarbital targets LKB1 for necessary activation of AMP-activated protein kinase

Transcriptional activation of cytochrome P450 (CYP) genes and various drug metabolizing enzymes by the prototypical inducer phenobarbital (PB) and many other drugs and chemicals is an adaptive response of the organism to exposure to xenobiotics. The response to PB is mediated by the nuclear receptor...

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Библиографические подробности
Главные авторы: Blättler, Sharon M., Rencurel, Franck, Kaufmann, Michel R., Meyer, Urs A.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2007
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1783361/
https://ncbi.nlm.nih.gov/pubmed/17213310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0610216104
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