Characterization of methyltransferase and hydroxylase genes involved in the biosynthesis of the immunosuppressants FK506 and FK520.

FK506 and FK520 are 23-membered macrocyclic polyketides with potent immunosuppressive and antifungal activities. The gene encoding 31-O-demethyl-FK506 methyltransferase, fkbM, was isolated from Streptomyces sp. strains MA6858 and MA6548, two FK506 producers, and Streptomyces hygroscopicus subsp. asc...

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Main Authors: Motamedi, H, Shafiee, A, Cai, S J, Streicher, S L, Arison, B H, Miller, R R
Format: Artigo
Jezik:Inglês
Izdano: 1996
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC178323/
https://ncbi.nlm.nih.gov/pubmed/8752344
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