Characterization of methyltransferase and hydroxylase genes involved in the biosynthesis of the immunosuppressants FK506 and FK520.

FK506 and FK520 are 23-membered macrocyclic polyketides with potent immunosuppressive and antifungal activities. The gene encoding 31-O-demethyl-FK506 methyltransferase, fkbM, was isolated from Streptomyces sp. strains MA6858 and MA6548, two FK506 producers, and Streptomyces hygroscopicus subsp. asc...

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Detalles Bibliográficos

Publicado en:	J Bacteriol
Principais autores:	Motamedi, H, Shafiee, A, Cai, S J, Streicher, S L, Arison, B H, Miller, R R
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Microbiology (ASM) 1996
Assuntos:	Research Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC178323/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8752344/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.178.17.5243-5248.1996
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