The immune dysregulatory compound mercuric chloride induces integrin-mediated T-lymphocyte adhesion

Exposure of Brown Norway rats to mercuric chloride induces systemic autoimmunity, involving T- and B-lymphocyte activation, (auto-)antibody production and multiorgan inflammation. Several divalent metal ions, such as Mg(2+) and Mn(2+), can activate binding of integrins to their ligands, thus causing...

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Autors principals: Roos, A, Neeft, M, Engelen, L, Schilder-Tol, E J M, Kunzendorf, U, Weening, J J, Aten, J
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 2001
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1783158/
https://ncbi.nlm.nih.gov/pubmed/11168634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2567.2001.01160.x
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