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Id1 restrains myeloid commitment, maintaining the self-renewal capacity of hematopoietic stem cells
Appropriate hematopoietic stem cell (HSC) self-renewal reflects the tight regulation of cell cycle entry and lineage commitment. Here, we show that Id1, a dominant-negative regulator of E protein transcription factors, maintains HSC self-renewal by preserving the undifferentiated state. Id1-deficien...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1783103/ https://ncbi.nlm.nih.gov/pubmed/17227850 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0607894104 |
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