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Id1 restrains myeloid commitment, maintaining the self-renewal capacity of hematopoietic stem cells

Appropriate hematopoietic stem cell (HSC) self-renewal reflects the tight regulation of cell cycle entry and lineage commitment. Here, we show that Id1, a dominant-negative regulator of E protein transcription factors, maintains HSC self-renewal by preserving the undifferentiated state. Id1-deficien...

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Bibliografski detalji
Glavni autori: Jankovic, Vladimir, Ciarrocchi, Alessia, Boccuni, Piernicola, DeBlasio, Tony, Benezra, Robert, Nimer, Stephen D.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2007
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1783103/
https://ncbi.nlm.nih.gov/pubmed/17227850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0607894104
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