Resistant mice lacking interleukin-12 become susceptible to Trypanosoma cruzi infection but fail to mount a T helper type 2 response

Interleukin-12 (IL-12) is essential to resistance to Trypanosoma cruzi infection because it stimulates the synthesis of interferon-γ (IFN-γ) that activates macrophages to a parasiticidal effect. Investigation of mice deprived of IL-12 genes (IL-12 knockout mice) has confirmed the important role of I...

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Autors principals: Galvão Da Silva, Ana Paula, Jacysyn, Jacqueline F, Abrahamsohn, Ises De Almeida
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 2003
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1782876/
https://ncbi.nlm.nih.gov/pubmed/12562332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2567.2003.01571.x
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