Augmented expression of tumour necrosis factor-α induced by lipopolysaccharide in spleen of human monocyte chemoattractant protein-1 transgenic mouse enhances the lipopolysaccharide sensitivity of the marginal zone macrophages

Monocyte chemoattractant protein-1 (MCP-1) is a protective cytokine in murine endotoxaemia induced by lipopolysaccharide (LPS). In this study, LPS-induced pathophysiology in the human (h) MCP-1 transgenic mouse (Tgm) line was investigated. The hMCP-1 Tgm showed a marked increase in the mortality and...

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Détails bibliographiques
Auteurs principaux: Ato, Manabu, Iwabuchi, Kazuya, Shimada, Shigeki, Mukaida, Naofumi, Onoé, Kazunori
Format: Artigo
Langue:Inglês
Publié: Blackwell Science Inc 2002
Sujets:
Original Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1782746/
https://ncbi.nlm.nih.gov/pubmed/12153519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2567.2002.01450.x
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