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Impaired germinal centre formation and humoral immune response in the absence of CD28 and interleukin-4
The generation of an optimal humoral immune response requires fully activated T-cells. For complete activation at least two signals are needed. The first one is an antigen dependent one via the T cell receptor, the second one is a costimulatory signal which can be delivered by the CD28 molecule afte...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Inc
2002
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1782711/ https://ncbi.nlm.nih.gov/pubmed/12047751 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2567.2002.01405.x |
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