Genetic fusion of human insulin B-chain to the B-subunit of cholera toxin enhances in vitro antigen presentation and induction of bystander suppression in vivo

The pentameric B-subunit of cholera toxin (CTB) can be used as an efficient mucosal carrier of either immunogenic or tolerogenic T-cell epitopes. In this study a series of fusions was constructed between the genes encoding CTB and the B-chain of human insulin (InsB). The resulting fusion proteins we...

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Библиографические подробности
Главные авторы: Sadeghi, Hamid, Bregenholt, Søren, Wegmann, Dale, Petersen, Jacob S, Holmgren, Jan, Lebens, Michael
Формат: Artigo
Язык:Inglês
Опубликовано: Blackwell Science Inc 2002
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Original Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1782710/
https://ncbi.nlm.nih.gov/pubmed/12047753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2567.2002.01413.x
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