Autoimmunity and glomerulonephritis in mice with targeted deletion of the serum amyloid P component gene: SAP deficiency or strain combination?

Human serum amyloid P component (SAP) binds avidly to DNA, chromatin and apoptotic cells in vitro and in vivo. 129\Sv × C57BL\6 mice with targeted deletion of the SAP gene spontaneously develop antinuclear autoantibodies and immune complex glomerulonephritis. SAP-deficient animals, created by backcr...

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Main Authors: Gillmore, Julian D, Hutchinson, Winston L, Herbert, Jeff, Bybee, Alison, Mitchell, Daniel A, Hasserjian, Robert P, Yamamura, Ken-Ichi, Suzuki, Misao, Sabin, Caroline A, Pepys, Mark B
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Science Inc 2004
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Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1782492/
https://ncbi.nlm.nih.gov/pubmed/15147569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2567.2004.01860.x
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