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Mice overexpressing p40 in lungs have reduced leucocyte influx and slightly impaired resistance during tuberculosis
Interleukin (IL)-12 (p70) is a heterodimeric cytokine composed of p40 and p35, that plays a major role in the protective immune response to Mycobacterium tuberculosis. To define the role of p40 in lungs during pulmonary M. tuberculosis infection we generated transgenic (Tg) mice overexpressing p40 u...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Inc
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1782238/ https://ncbi.nlm.nih.gov/pubmed/16476061 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2567.2005.02315.x |
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