Mice overexpressing p40 in lungs have reduced leucocyte influx and slightly impaired resistance during tuberculosis

Interleukin (IL)-12 (p70) is a heterodimeric cytokine composed of p40 and p35, that plays a major role in the protective immune response to Mycobacterium tuberculosis. To define the role of p40 in lungs during pulmonary M. tuberculosis infection we generated transgenic (Tg) mice overexpressing p40 u...

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Detaylı Bibliyografya
Asıl Yazarlar: Leemans, Jaklien C, Wieland, Catharina W, Florquin, Sandrine, van der Poll, Tom, Vervoordeldonk, Margriet J B M
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Blackwell Science Inc 2006
Konular:
Original Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1782238/
https://ncbi.nlm.nih.gov/pubmed/16476061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2567.2005.02315.x
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