Reduced susceptibility to dextran sulphate sodium-induced colitis in the interleukin-2 heterozygous (IL-2(+/−)) mouse

Mice homozygous for an inactivation of the interleukin-2 (IL-2) gene develop a T-cell dependent colitis. Heterozygous (IL-2(+/−)) mice are clinically healthy but have been shown to express reduced levels of IL-2 in the colon. Splenocytes from the IL-2(+/−) mice had a poorer proliferative response to...

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Main Authors: Sund, Malin, Xu, Li Li, Rahman, Arman, Qian, Bi-Feng, Hammarström, Marie-Louise, Danielsson, Åke
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2005
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1782116/
https://ncbi.nlm.nih.gov/pubmed/15804292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2567.2005.02123.x
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