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Mass spectrometry-based detection of transfer RNAs by their signature endonuclease digestion products

The separation of biologically active, pure, and specific tRNAs is difficult due to the overall similarity in secondary and tertiary structures of different tRNAs. Because prior methods do not facilitate high-resolution separations of the extremely complex mixture represented by a cellular tRNA popu...

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Autors principals: Hossain, Mahmud, Limbach, Patrick A.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2007
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1781365/
https://ncbi.nlm.nih.gov/pubmed/17194720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.272507
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