IgVH genes from different anatomical regions, with different histopathological patterns, of a rheumatoid arthritis patient suggest cyclic re-entry of mature synovial B-cells in the hypermutation process

INTRODUCTION: Although IgV genes in rheumatoid B cells have been intensively analyzed, many questions concerning antigen driven B-cell maturation and recirculation remain unanswered. It would be interesting to know whether B-cell maturation in rheumatoid tissue is different from that in secondary ly...

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Veröffentlicht in:	Arthritis Res
Hauptverfasser:	Souto-Carneiro, Maria M, Krenn, Veit, Hermann, Ralph, König, Achim, Müller-Hermelink, Hans-Konrad
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2000
Schlagworte:	Primary Research
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC17813/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11056671/ https://ncbi.nlm.nih.govhttps://doi.org/10.1186/ar105
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