IgVH genes from different anatomical regions, with different histopathological patterns, of a rheumatoid arthritis patient suggest cyclic re-entry of mature synovial B-cells in the hypermutation process

INTRODUCTION: Although IgV genes in rheumatoid B cells have been intensively analyzed, many questions concerning antigen driven B-cell maturation and recirculation remain unanswered. It would be interesting to know whether B-cell maturation in rheumatoid tissue is different from that in secondary ly...

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Main Authors: Souto-Carneiro, Maria M, Krenn, Veit, Hermann, Ralph, König, Achim, Müller-Hermelink, Hans-Konrad
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2000
Fag:
Primary Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC17813/
https://ncbi.nlm.nih.gov/pubmed/11056671
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