Inhibition of Tumor Endothelial ERK Activation, Angiogenesis, and Tumor Growth by Sorafenib (BAY43-9006)

Activation of the Raf-MEK-ERK signal transduction pathway in endothelial cells is required for angiogenesis. Raf is the kinase most efficiently inhibited by the multikinase inhibitor sorafenib, which has shown activity against certain human cancers in clinical trials. To understand the mechanisms un...

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Bibliografiske detaljer
Main Authors: Murphy, Danielle A., Makonnen, Sosina, Lassoued, Wiem, Feldman, Michael D., Carter, Christopher, Lee, William M.F.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2006
Fag:
Regular Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1780219/
https://ncbi.nlm.nih.gov/pubmed/17071608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2006.050711
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