Platelet-Derived Growth Factor-BB Controls Epithelial Tumor Phenotype by Differential Growth Factor Regulation in Stromal Cells

Platelet-derived growth factor (PDGF) stimulates tumor growth and progression by affecting tumor and stromal cells. In the HaCaT skin carcinogenesis model, transfection of immortal nontumorigenic and PDGF-receptor-negative HaCaT keratinocytes with PDGF-B induced formation of benign tumors. Here, we...

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Библиографические подробности
Главные авторы: Lederle, Wiltrud, Stark, Hans-Jürgen, Skobe, Mihaela, Fusenig, Norbert E., Mueller, Margareta M.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Investigative Pathology 2006
Предметы:
Regular Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1780216/
https://ncbi.nlm.nih.gov/pubmed/17071599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2006.060120
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