Overexpression of Peroxisome Proliferator-Activated Receptor γ Co-Activator-1α Leads to Muscle Atrophy with Depletion of ATP

Peroxisome proliferator-activated receptor-γ co-activator-1α (PGC-1α) is a key nuclear receptor co-activator for mitochondrial biogenesis. Here we report that overexpression of PGC-1α in skeletal muscles increased mitochondrial number and caused atrophy of skeletal muscle, especially type 2B fiber-r...

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Detalhes bibliográficos
Main Authors: Miura, Shinji, Tomitsuka, Eriko, Kamei, Yasutomi, Yamazaki, Tomomi, Kai, Yuko, Tamura, Mayumi, Kita, Kiyoshi, Nishino, Ichizo, Ezaki, Osamu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2006
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1780180/
https://ncbi.nlm.nih.gov/pubmed/17003473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2006.060034
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