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PIK3CA Mutations in Intraductal Papillary Mucinous Neoplasm/Carcinoma (IPMN/IPMC) of the Pancreas

BACKGROUND: Recent studies have reported high frequencies of somatic mutations in the phosphoinositide-3-kinase, catalytic, alpha (PIK3CA) gene in various human solid tumors. More than 75% of those somatic mutations are clustered in the helical (exon 9) and kinase domains (exon 20). The three hot-sp...

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Main Authors: Schönleben, Frank, Qiu, Wanglong, Ciau, Nancy T., Ho, Daniel J., Li, Xiaojun, Allendorf, John D., Remotti, Helen E., Su, Gloria H.
格式: Artigo
語言:Inglês
出版: 2006
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1780026/
https://ncbi.nlm.nih.gov/pubmed/16778113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-06-0292
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