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Curvature and Hydrophobic Forces Drive Oligomerization and Modulate Activity of Rhodopsin in Membranes

G protein-coupled receptors (GPCRs) are essential components of cellular signaling pathways. They are the targets of many current pharmaceuticals and are postulated to dimerize or oligomerize in cellular membranes in conjunction with their functional mechanisms. We demonstrate using fluorescence res...

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Detalhes bibliográficos
Main Authors: Botelho, Ana Vitória, Huber, Thomas, Sakmar, Thomas P., Brown, Michael F.
Formato: Artigo
Idioma:Inglês
Publicado em: Biophysical Society 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1779922/
https://ncbi.nlm.nih.gov/pubmed/17012328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.082776
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