Two distinct loci affecting conversion to mucoidy in Pseudomonas aeruginosa in cystic fibrosis encode homologs of the serine protease HtrA.

Conversion to a mucoid, exopolysaccharide alginate-overproducing phenotype in Pseudomonas aeruginosa is associated with chronic respiratory infections in cystic fibrosis. Mucoidy is caused by muc mutations that derepress the alternative sigma factor AlgU, which in turn activates alginate biosyntheti...

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Bibliographic Details
Main Authors: Boucher, J C, Martinez-Salazar, J, Schurr, M J, Mudd, M H, Yu, H, Deretic, V
Format: Artigo
Language:Inglês
Published: 1996
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC177686/
https://ncbi.nlm.nih.gov/pubmed/8550474
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