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Structure-activity relations for the inhibition of 5-hydroxytryptamine uptake by tricyclic antidepressants into synaptosomes from serotoninergic neurones in rat brain homogenates

1 The inhibitory effects of various analogues of imipramine on [(3)H]-5-hydroxytryptamine (5-HT) uptake into homogenates of rat hypothalamus were examined. 2 For structures with a three carbon side chain the tertiary amine derivative was more potent than the compound with a secondary amine function....

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Библиографические подробности
Главные авторы: Horn, A.S., Trace, R.C.A.M.
Формат: Artigo
Язык:Inglês
Опубликовано: 1974
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1776771/
https://ncbi.nlm.nih.gov/pubmed/4451753
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