A transgene insertion creating a heritable chromosome deletion mouse model of Prader-Willi and Angelman syndromes

Prader-Willi syndrome (PWS) and Angelman syndrome (AS) result from the loss of function of imprinted genes in human chromosome 15q11–q13. The central part of mouse chromosome 7 is homologous to human 15q11–q13, with conservation of both gene order and imprinted features. We report here the character...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Gabriel, J. M., Merchant, M., Ohta, T., Ji, Y., Caldwell, R. G., Ramsey, M. J., Tucker, J. D., Longnecker, R., Nicholls, R. D.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC17767/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10430930/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.16.9258
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