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Cellular and metabolic tolerance to an opioid narcotic in mouse brain

1. Running activity and brain levorphanol concentration were measured in nontolerant and tolerant mice given various doses of (3)H-levorphanol. 2. The principal factor responsible for tolerance in the mouse is a loss of sensitivity to the narcotic drug at the cellular level in brain; despite adequat...

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Bibliografske podrobnosti
Main Authors: Goldstein, A., Judson, Barbara A., Sheehan, Patricia
Format: Artigo
Jezik:Inglês
Izdano: 1973
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1776531/
https://ncbi.nlm.nih.gov/pubmed/4717014
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