In vivo CpG DNA/toll-like receptor 9 interaction induces regulatory properties in CD4(+)CD62L(+) T cells which prevent intestinal inflammation in the SCID transfer model of colitis

Background and methods: Cytosin-guanosin dinucleotide (CpG) motifs of bacterial DNA are known to be potent activators of innate immunity. We have shown previously that administration of CpG containing oligodeoxynucleotide (CpG-ODN) to mice before the onset of dextran sodium sulphate induced colitis...

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Autores principales: Obermeier, F, Strauch, U G, Dunger, N, Grunwald, N, Rath, H C, Herfarth, H, Schölmerich, J, Falk, W
Formato: Artigo
Lenguaje:Inglês
Publicado: Copyright 2005 by Gut 2005
Materias:
Inflammatory Bowel Disease
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1774700/
https://ncbi.nlm.nih.gov/pubmed/15879013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gut.2004.046946
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