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NF-κB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes

Activation of CD40 is essential for thymus-dependent humoral immune responses and rescuing B cells from apoptosis. Many of the effects of CD40 are believed to be achieved through altered gene expression. In addition to Bcl-x, a known CD40-regulated antiapoptotic molecule, we identified a related ant...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Lee, Ho H., Dadgostar, Hajir, Cheng, Qingwen, Shu, Junyan, Cheng, Genhong
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1999
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC17745/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10430908/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.16.9136
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