CD4(+)CD45RB(Hi) T cell transfer induced colitis in mice is accompanied by osteopenia which is treatable with recombinant human osteoprotegerin

Background and aims: Transfer of CD4(+)CD45RB(Hi) T cells into semi syngeneic immunodeficient mice represents a model of inflammatory bowel disease (IBD). As patients with IBD often suffer from osteopenia, we studied if this T cell transfer in mice results in osteopenia in addition to colitis, and i...

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Bibliographic Details
Main Authors: Byrne, F R, Morony, S, Warmington, K, Geng, Z, Brown, H L, Flores, S A, Fiorino, M, Yin, S L, Hill, D, Porkess, V, Duryea, D, Pretorius, J K, Adamu, S, Manuokian, R, Danilenko, D M, Sarosi, I, Lacey, D L, Kostenuik, P J, Senaldi, G
Format: Artigo
Language:Inglês
Published: Copyright 2005 by Gut 2005
Subjects:
Inflammatory Bowel Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1774360/
https://ncbi.nlm.nih.gov/pubmed/15591508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gut.2003.035113
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